What Episode Does Fullmetal Alchemist Change?
In Fullmetal Alchemist: Brotherhood, the change happens roughly by episode 13 when it starts getting into new material not covered in the original anime.
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You might be talking about when the story veers off from the manga in the 2003 series, which happens around episode 25.
Honestly, just start from the beginning. The anime is legendary from episode 1.
If by change you mean when the plot takes a major twist, that's a bit subjective, but episode 25 in the 2003 series is a significant point.
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