Can you remove perks in Fallout 4?
Nope, once you've picked a perk in Fallout 4, it's yours for good. Choose wisely because there's no take-backsies in the wasteland.
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Actually, you can't directly remove perks that you've chosen. However, with PC mods or console commands, you can kinda 'reset' your perks, but that's not an official game feature. So, stick to your choices or get creative!
Short answer: No. Long answer: Still no, but mods and console commands can offer a workaround for the creatively desperate.
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