Can you respond during Double Strike damage in MTG?
Nope, you can't. Once combat and damage steps start rolling, especially with Double Strike, the damage happens in two phases (first strike and regular combat damage) without a chance for you to cast spells or activate abilities in between. You have to play your tricks before combat damage or in between combat phases.
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Actually, during the double strike phase, you get a brief moment after the first strike damage to cast instants or activate abilities before the regular combat damage kicks in. It's like a sneak attack window!
Short answer: no. Once combat starts, you're pretty much a spectator until the dust settles.
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