How to Clean a PS3 Disc Reader
First, unplug your PS3 and carefully open the disc tray. Use a can of compressed air to blow out dust and debris. If it's still dirty, gently wipe the lens with a microfiber cloth dampened with isopropyl alcohol. Handle everything with care!
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The safest way is to use a lens cleaning disc specifically made for consoles. Just pop it in and follow the instructions!
I once used a cotton swab with a bit of lens cleaner on my PS3. Worked like a charm! Make sure to be gentle though.
Here's my hot take: just take it to a professional. DIY cleaning can easily mess up the internals.
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