How to Fight Satan in The Binding of Isaac: Afterbirth+

Best Answer

Defeat Mom's Heart or It Lives, then go to the Devil Room and find the trapdoor to Sheol. Satan will be waiting for you there!

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More Answers

EmptyingDaisy·3 months ago

To fight Satan, you'll need to beat Mom's Heart or It Lives, then enter the Devil Room that appears. Take the trapdoor to Sheol, and make your way to the boss room.

WipingBride·3 months ago

After defeating Mom's Heart/It Lives, look for a trapdoor in the Devil Room that takes you to Sheol. Fight your way to Satan's lair!

ScoldingIrony·3 months ago

I once beat Satan by going through Sheol after crushing Mom's Heart. Just keep an eye out for that Devil Room trapdoor!

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