How to Make The Binding of Isaac Afterbirth Run Faster
Close other applications when playing. Isaac deserves your PC's full attention!
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Run the game in windowed mode. It often boosts performance compared to fullscreen.
Make sure your graphics drivers are up to date. Sometimes just updating them can give you a decent performance boost.
If you're playing on PC, consider using a performance optimization tool like Game Mode on Windows 10. These can help prioritize the game over other background processes.
First, try lowering the graphics settings — turn off V-Sync and lower the resolution. You can also close any background applications that might be hogging resources.
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