What game engine does The Binding of Isaac use?
The Binding of Isaac was developed with Adobe Flash. When it got revamped in 2014 as Rebirth, it moved to a custom engine based on C++.
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Isaac started with Adobe Flash, but Rebirth uses a custom engine written in C++ for better performance and graphics.
Hot take: who needs the engine details when the game is this good? Just play it!
I remember the devs saying they first used Adobe Flash and then created a custom C++ engine for Rebirth. Less lag and richer graphics!
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